Endocrine Abstracts

: A large number of studies are now focused on the causes of male infertility. Among these are epigenetic modifications, which are important contributors to reproductive pathology in the male by providing dynamic changes of the phenotype according to the environmental and metabolic factors. The most known epigenetic modification is DNA methylation and alterations in this pattern in several genes could induce male infertility. Alterations in DNA methylation patterns in several ...

The CDX2 VDR polymorphism (rs11568820) is located in the promoter region of exon 1 in the 5′-untranslated region of the VDR gene.Objective: The current investigation examines the association between CDX2 VDR polymorphism and male infertility.Subjects and methods: The study was conducted on 69 infertile men, aged between 20 and 50 years, divided into three groups, based on spermatic parameters: group with azoospermia (19 subje...

Only a few genes involved in spermatogenesis have clinical importance: Y chromosome micro deletions in the region called azoospermia factor (AZF) and oestrogen receptor alpha gene polymorphisms (ESR1).Objective: The study aim to evaluate ESR1 and Y chromosome deletion in infertile men.Subjects and methods: 43 infertile men, and 34 fertile men aged 20–50 years 50, were enrolled after signing the informed consent. Screening for ...